Major effect of transcytosis on nano drug delivery to pancreatic cancer

Major effect of transcytosis on nano drug delivery to pancreatic cancer

Blog Article

We demonstrated that activated transcytosis is a major mechanism to complement the classic enhanced permeability and retention effect in pancreatic cancer.This Mug was achieved by using an iRGD peptide that triggers transcytosis pathway at the tumor site.Co-administration of unconjugated iRGD substantially improved the effect of the chemotherapeutics delivering nanocarrier, and resulted in survival improvement in Diecast Car mice.

Since the iRGD effect is commensurate with neuropilin-1 expression on tumor vasculature, it is necessary to contemplate a personalized approach to implement this technology.